Journal of HIV and Human Reproduction

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 4  |  Issue : 1  |  Page : 20--26

Troponin I as marker of subclinical cardiac injury in human immunodeficiency virus-seropositive patients in Sokoto, Nigeria


Aminu Bello1, Abdullah S Mainasara1, Hamidu M Liman2, Umar Hayatu2, Abdullahi F Abubakar1, Kasimu Saidu1, Bashar Sani3, Aminu A Umar4 
1 Department of Chemical Pathology and Immunology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
2 Department of Internal Medicine, Faculty of Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
3 Department of Chemical Pathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
4 Department of Morbid Anatomy and Forensic Medicine, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria

Correspondence Address:
Aminu Bello
Department of Chemical Pathology and Immunology, Faculty of Basic Medical Sciences College of Health Sciences, Usmanu Danfodiyo University, Sokoto
Nigeria

INTRODUCTION: Myocardial injury remains a challenging health issue among human immunodeficiency virus (HIV)/acquired immuno deficiency syndrome patients, and the importance for the estimation of cardiac troponin I (cTnI) as a tool for early detection of cardiac injury has been proven by many studies. This study examined the specificity of cTnI estimation and other cardiac enzymes in detection of subclinical cardiac injury in HIV-positive patients. MATERIALS AND METHODS: One hundred and forty patients and 70 controls between the ages of 15–80 years were studied. The patients were grouped into three categories: seventy patients on highly active antiretroviral therapy (HAART), seventy on HAART-naïve patients, and seventy were recruited as controls. RESULTS: The values (mean ± standard error of mean) of cTnI, total creatine kinase (TCK), creatine kinase muscle and brain subtype (CKMB), and lactate dehydrogenase (LDH) in patients on HAART were 3.32 ± 0.32 ng/mL, 83.52 ± 9.69 IU/L, 30.79 ± 2.02 IU/L, and 517.4 ± 19.23 IU/L, respectively. For the HAART-naïve patients, the values were 2.37 ± 0.22 ng/mL, 72.53 ± 6.47 IU/L, 51.02 ± 10.86 IU/L, and 439 ± 17.72 IU/L whereas for controls the values were 1.62 ± 0.19 ng/mL, 54.86 ± 5.82 IU/L, 15.60 ± 1.63 IU/L, and 355.30 ± 23.40 IU/L with P values <0.0001, 0.0265, 0.0007, <0.0001 which were statistically significant for cTnI, TCK, CKMB, and LDH, respectively. However, all the parameters studied were found to be elevated in patients than in the controls. CONCLUSIONS: The study showed that about 121 (86.4%) of studied cases had elevated serum cTnI, of which 65 (53.7%) had elevated serum CKMB which strongly suggested subclinical myocardial injury among majority of the HIV-seropositive patients in this study.


How to cite this article:
Bello A, Mainasara AS, Liman HM, Hayatu U, Abubakar AF, Saidu K, Sani B, Umar AA. Troponin I as marker of subclinical cardiac injury in human immunodeficiency virus-seropositive patients in Sokoto, Nigeria.J HIV Hum Reprod 2016;4:20-26


How to cite this URL:
Bello A, Mainasara AS, Liman HM, Hayatu U, Abubakar AF, Saidu K, Sani B, Umar AA. Troponin I as marker of subclinical cardiac injury in human immunodeficiency virus-seropositive patients in Sokoto, Nigeria. J HIV Hum Reprod [serial online] 2016 [cited 2019 Feb 20 ];4:20-26
Available from: http://www.j-hhr.org/article.asp?issn=2321-9157;year=2016;volume=4;issue=1;spage=20;epage=26;aulast=Bello;type=0