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Year : 2016  |  Volume : 4  |  Issue : 1  |  Page : 8-12

The human immunodeficiency virus infection is associated with positive iron balance among subjects in Nnewi, South East Nigeria

1 Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
2 Department of Haematology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
3 Clinical Services, Initiative for Good Health in , Enugu, Nigeria

Correspondence Address:
John C Aneke
Department of Haematology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001, Nnewi, Anambra State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jhhr.jhhr_2_17

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BACKGROUND: The human immunodeficiency virus (HIV) infection is associated with a number of metabolic derangements which have a remarkable impact on disease mortality and morbidity. OBJECTIVE: To evaluate the effect of HIV infection on iron status in apparently healthy seropositive adult subjects seen at a tertiary hospital in South East Nigeria. SUBJECTS AND METHODS: A total of eighty subjects were recruited for the study which comprised of randomly selected forty HIV seropositive and seronegative individuals, respectively. Each participant had 5 ml of blood collected for serum ferritin, iron, total binding capacity (TIBC), and percentage saturation of transferrin estimation. Ferritin was determined using the enzyme-linked immunosorbent assay technique while iron and TIBC were measured by spectrophotometry; percentage transferrin saturation was calculated using the standard formula. Statistical analysis was performed using SPSS (version 20), the Student's t-test was used for the comparison of means while the level of statistical significance was set at P< 0.05. RESULTS: The means of serum ferritin and transferrin saturation were significantly higher (164.30 ± 138.52 ng/ml vs. 88.10 ± 57.75 ng/ml; P= 0.002 and 44.67 ± 12.95% vs. 32.42 ± 4.67%; P< 0.001, respectively) while the mean of serum TIBC was significantly lower (346.25 ± 81.83 μg/dl vs. 395.20 ± 66.70 μg/dl; P= 0.004, respectively) in test subjects compared with controls. Serum iron was not significantly different in the two populations of study subjects (P = 0.30). CONCLUSION: Infection with the HIV is associated with significant tissue iron loading; this could have important implications on disease course and morbidity.

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